Human IL-12 P40

DESCRIPTION

Interleukin 12 (IL-12) is an interleukin that is naturally produced by dendritic cells, macrophages and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation. IL-12 is composed of a bundle of four alpha helices. It is a heterodimeric cytokine encoded by two separate genes, IL-12A (p35) and IL-12B (p40). IL-12 plays an important role in the activities of natural killer cells and T lymphocytes. It mediates enhancement of the cytotoxic activity of NK cells and CD8+ cytotoxic T lymphocytes. IL-12 also has anti-angiogenic activity, which means it can block the formation of new blood vessels. IL12 p40 exists as a monomer and as a homodimer. The IL12B gene contains 8 exons, and maps to 5q31-q33.

DETAILS

OMIM: 161561
Gene ID: 3593
SwissProt: P29460
Test Range: 31.2 pg/ml-2000 pg/ml
Alias Names: Subunit beta of interleukin 12, IL-12B, natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor p40, interleukin-12 subunit p40, IL12B, CLMF, CLMF2, IL-12B, IMD28, NKSF, NKSF2, IMD29, Interleukin 12 subunit beta, interleukin 12B, IL12B, IL 12beta, IL 12B, Cytotoxic lymphocyte maturation factor 40 kDa subunit, CLMF p40, p40, IL-12 subunit p40, NK cell stimulatory factor chain 2, NKSF2, IL-12P40, IL12P40, P40, IL 12P40
Application: Quantitative ELISA
Sensitivity: < 2pg/ml
Test Samples: For quantitative detection of IL-12(P40) in human serum, plasma, body fluids, tissue lysates or cell culture supernatants.
Detection Method: Sandwich Enzyme-Linked Immune-sorbent Assay
Species Reactivity: Human
Storage Instruction: Store at 2-8℃ for 6 months, or at -20℃ for 12 months.