LR5-C52H3-100ug LR5-C52H3-1mg
Cynomolgus / Rhesus macaque LRRC15 Protein, His Tag (MALS verified)
ACROBiosystems
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DESCRIPTION
LRRC15 (Leucine-rich repeat-containing protein 15) is also known as LIB and hLib. LRRC15 is highly expressed in a variety of solid tumors. LRRC15 was expressed on stromal fibroblasts in many solid tumors (e.g., breast, head and neck, lung, pancreatic) as well as directly on a subset of cancer cells of mesenchymal origin (e.g., sarcoma, melanoma, glioblastoma). LRRC15 expression was induced by TGFβ on activated fibroblasts (αSMA+) and on mesenchymal stem cells. These collective findings suggested LRRC15 as a novel CAF and mesenchymal marker with utility as a therapeutic target for the treatment of cancers with LRRC15-positive stromal desmoplasia or cancers of mesenchymal origin. ABBV-085 is a monomethyl auristatin E (MMAE)-containing antibody–drug conjugate (ADC) directed against LRRC15, and it demonstrated robust preclinical efficacy against LRRC15 stromal-positive/cancer-negative, and LRRC15 cancer-positive models as a monotherapy, or in combination with standard-of-care therapies.
DETAILS
- Tag: C-10×His
- Host: HEK293
- Size: 1mg
- Buffer: PBS, pH7.4
- Format: Powder
- Purity: 90%
- Source: Cynomolgus / Rhesus macaque LRRC15 Protein, His Tag (LR5-C52H3) is expressed from human 293 cells (HEK293). It contains AA Tyr 22 - Gly 538 (Accession # A0A2K5UKB6-1).
- Storage: -20℃
- Category: Other Recombinant Proteins
- Molecule: LRRC15
- Conjugate: Unconjugated
- Stability: ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
- Exp Region: Tyr 22 - Gly 538
- Swiss-prot: A0A2K5UKB6-1
- Package Size: 500ug*2
- Characteristics: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 59.9 kDa. The protein migrates as 75-90 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
- Endotoxin Level: 1.0 EU per μg
- Molecular Weight: 59.9 kDa
- Shipping Condition: RT
- Species Reactivity: Cynomolgus / Rhesus macaque
- Extra Shippinghandling Fee: Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/A48-Shipping-and-Payments.html