79679-MSM1-P0 79679-MSM1-P1 79679-MSM1-P1ABX
B7-H4 (Immuno-Inhibitory Protein) - CloneID - B7H4/1788
NeoBiotechnologies
DESCRIPTION
T cell activation and immune function are regulated by the innate immune system through positive and negative costimulatory proteins. One such protein, B7-H4 (B7-homolog 4), belongs to the B7 immunoglobulin superfamily of ligand-lymphocyte interacting proteins. Expressed primarily on the membrane of lymphoid cells, B7-H4 is an immuno-inhibitory protein that interacts with receptors on the surface of T lymphocytes, thus mediating cellular and humoral immune responses. Overexpression of the B7-H4 protein is associated with certain malignancies, including ovarian and breast cancer, as its interaction with T cells suppresses tumor-associated immunity. Current research suggests that, similar to Mucin 16 (CA-125), B7-H4 may be a useful biomarker for the early detection of ovarian cancer.
DETAILS
- Host: Mouse
- Gene ID: 79679
- Uniprot: Q7Z7D3
- Clone ID: B7H4/1788
- Clonality: Monoclonal
- Gene Name: VTCN1
- Supplied As: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
- Applications: FLOW, IHC, WB, IF
- Protein Target: VTCN1
- Species Reactivity: Human
- Storage Conditions: Antibody with azide - store at 2 to 8C. Antibody without azide - store at -20 to -80 C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.