mouse monoclonal IgG2a; TH Antibody (F-11) is an IgG2a κ mouse monoclonal TH antibody (also designated tyrosine hydroxylase antibody, or TYH antibody) that detects the TH protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA.Tyrosine hydroxylase Antibody (F-11) is available as both the non-conjugated anti-TH antibody form, as well as multiple conjugated forms of anti-TH antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The enzyme tyrosine hydroxylase (TH), also designated tyrosine 3-monooxygenase (TY3H), catalyzes the conversion of tyrosine to L-dopa, which is the rate limiting step in the biosynthesis of catecholamines such as dopamine, adrenalin and noradrenalin. TH is thought to play a role in the pathogenesis of Parkinson's disease, which is associated with reduced dopamine levels. Two transcription factor binding sites in the proximal region of the TH gene, the TPA-responsive element (TRE) and the c-AMP responsive element (CRE), have been implicated in the complex regulation of the TH gene. TH is also known to be upregulated by the glia maturation factor (GMF), a Cdc 10/SWI6 motif-containing protein called V-1, and a variety of additional compounds.