E1992Hu
Human Ryanodine Receptor 1, RYR1 ELISA Kit
Bioassay Technology Laboratory
DESCRIPTION
Calcium Channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules (PubMed: 11741831, PubMed: 16163667). Repeated very high-level exercise increases the open probability of the Channel and leads to Ca(2+) leaking into the cytoplasm (PubMed: 18268335). Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis (By similarity).
DETAILS
- GeneID: 6261
- Species: Human
- Storage: 2-8ºC
- MASS(Da): 565,176
- Synonyms: Ryanodine receptor 1;RYR 1;RYR1;RYR-1;Skeletal muscle calcium release Channel;Skeletal muscle ryanodine receptor;Skeletal muscle-type ryanodine receptor;Type 1 ryanodine receptor
- Assay Time: 1h 30m
- Assay Type: Sandwich
- Gene Names: RYR1
- Reactivity: Human
- Sample Type: Serum, plasma, cell culture supernates
- Sensitivity: 0.05ng/ml
- Target Protein: RYR1
- Detection Range: 0.1-30ng/ml
- Full Product Name: Ryanodine Receptor 1
- Standard Solution: 32ng/ml
- UniProt Accession: P21817