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sc-373844 SAMPLE sc-373844

Promo Available Scientist.com Supplier

DNA pol λ (E-11)

Santa Cruz Biotechnology

DESCRIPTION

mouse monoclonal IgG1; DNA pol λ Antibody (E-11) is an IgG1 κ mouse monoclonal DNA pol lambda antibody (also designated DNA pol λ antibody) that detects the DNA pol lambda protein of human origin by WB, IP, IF and ELISA. DNA pol λ Antibody (E-11) is available as both the non-conjugated anti-DNA pol lambda antibody form, as well as multiple conjugated forms of anti-DNA pol lambda antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. DNA polymerase lambda (pol λ), also designated DNA polymerase κ or Pol β2, is a low-fidelity polymerase which plays a role in both spontaneous and DNA damage-induced mutagenesis. Encoded by the POLL gene, pol λ is a member of the DNA polymerase type-X family. Pol λ extends primer-terminal mispairs opposite nondamaged DNA templates, suggesting that it may assist in extending mismatched base pairs during normal DNA replication. In addition, pol λ may play a role in the mutagenic bypass of T-T dimers. Proliferating cell nuclear antigen (PCNA), a protein essential to DNA replication, interacts with pol λ and thus influences the ability of pol λ to synthesize DNA.

DETAILS

  • Host: mouse
  • Type: Primary
  • Uniprot: Q9UGP5
  • Clonality: Monoclonal
  • Conjugate: unconjugated
  • Applications: WB, IP, IF, ELISA
  • Human Gene Id: 27343
  • Protein Target: DNA pol λ
  • Human Gene Name: POLL
  • Species Reactivity: human

PROMOTION TERMS

Free sample available. Limit 3 free samples for each full size Santa Cruz Biotechnology primary antibody ordered. All samples must be different. Customer responsible for shipping costs.