T22891
KL001
TargetMol
DETAILS
- Cas: 309928-48-1
- Purity: 98.85%
- Smiles: CS(=O)(=O)N(CC(O)CN1C2=CC=CC=C2C2=CC=CC=C12)CC1=CC=CO1
- Category: Compound
- Molecular Weight: 398.48
- Molecular Formula: C21H22N2O4S
DESCRIPTION
KL 001 is a Cryptochrome protein (CRY) stabilizer. KL001 prevented ubiquitin-dependent degradation of CRY, resulting in lengthening of the circadian period. KL001-mediated CRY stabilization inhibited glucagon-induced gluconeogenesis in primary hepatocytes. KL001 thus provides a tool to study the regulation of CRY-dependent physiology and aid development of clock-based therapeutics of diabetes.
Lead Time: 4 - 5 weeks
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