GMP-PDBH19-50ug GMP-PDBH19-500ug GMP-PDBH19-1mg
GMP Human PDGF-BB Protein
ACROBiosystems
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DESCRIPTION
PDGFs are mitogenic during early developmental stages, driving the proliferation of undifferentiated mesenchyme and some progenitor populations. During later maturation stages, PDGF signalling has been implicated in tissue remodelling and cellular differentiation, and in inductive events involved in patterning and morphogenesis. In addition to driving mesenchymal proliferation, PDGFs have been shown to direct the migration, differentiation and function of a variety of specialised mesenchymal and migratory cell types, both during development and in the adult animal. Other growth factors in this family include vascular endothelial growth factors B and C (VEGF-B, VEGF-C)which are active in angiogenesis and endothelial cell growth, and placenta growth factor (PlGF) which is also active in angiogenesis. PDGF plays a role in embryonic development, cell proliferation, cell migration, and angiogenesis. PDGF is a required element in cellular division for fibroblast, a type of connective tissue cell. PDGF is also known to maintain proliferation of oligodendrocyte progenitor cells. Platelet-derived growth factor subunit B is also known as PDGFB, FLJ12858, PDGF2, SIS, SSV, c-sis, is a member of the platelet-derived growth factor family. PDGFB can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma.
DETAILS
- Tag: Native
- Host: E. coli
- Size: 500ug
- Buffer: 20 mM Citric acid - Sodium Citrate, pH3.0
- Format: Powder-GMP
- Purity: 95%
- Source: GMP Human PDGF-BB Protein (GMP-PDBH19) is expressed from E. coli cells. It contains AA Ser 82 - Thr 190 (Accession # P01127-1).
- Storage: -20℃
- Category: Cytokines&Growth Factors
- Molecule: PDGF-BB
- Conjugate: Unconjugated
- Stability: ● -20°C to -70°C for 5 years in lyophilized state; ● -70°C for 12 months under sterile conditions after reconstitution. Upon receipt, store it immediately at -20°C or lower for long term storage.
- Exp Region: Ser 82 - Thr 190
- Swiss-prot: P01127-1
- Package Size: 50ug*10
- Characteristics: This protein carries no "tag". The protein has a calculated MW of 12.4 kDa. The protein migrates as 13 kDa±3 kDa under reducing (R) condition (SDS-PAGE).
- Endotoxin Level: 10 EU/mg
- Molecular Weight: 12.4 kDa
- Shipping Condition: Blue ice
- Species Reactivity: Human
- Extra Shippinghandling Fee: Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/A48-Shipping-and-Payments.html