mouse monoclonal IgG1; MTMR5 Antibody (B-9) is an IgG1 κ mouse monoclonal MTMR5 antibody (also designated MTMR5 antibody) that detects the MTMR5 protein of mouse, rat and human origin by WB, IP, IF and ELISA. MTMR5 Antibody (B-9) is available as both the non-conjugated anti-MTMR5 antibody form, as well as multiple conjugated forms of anti-MTMR5 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Myotubularin and the myotubularin-related proteins (MTMR1-9) belong to a highly conserved family of eukaryotic phosphatases. They are protein tyrosine phosphatases that utilize inositol phospholipids, rather than phosphoproteins, as substrates. MTMR family members hydrolyze both Phosphatidylinositol 3-phosphate (PtdIns3P) and PtdIns(3,5)P2. MTMR2 interacts with MTMR5, an inactive family member that increases the enzymatic activity of MTMR2 and dictates its subcellular localization. Mutations in MTMR2 cause autosomal recessive Charcot-Marie-Tooth type 4B1 (CMT4B1), which is characterized by reduced nerve conduction velocities, focally folded myelin sheaths and demyelination. MTMR3 and MTMR4 can either interact with each other or self associate. MTMR6 regulates the activity of the calcium-activated potassium channel 3.1. MTMR9 regulates the activity of MTMR7 and MTMR8.

Free sample available. Limit 3 free samples for each full size Santa Cruz Biotechnology primary antibody ordered. All samples must be different. Customer responsible for shipping costs.