Phospho-Jak1 (Tyr1022/1023) (Clone: F11) rabbit mAb APC Conjugate

DESCRIPTION

Jak1 plays an essential role in the IFN- alpha and IFN-g response pathways and is tyrosine-phosphorylated upon cellular exposure to these signals. Jak1 oral inhibitors have been used to benefit patients with advanced myelofibrosis, where Jak1 was initially shown to be constitutively active in the peripheral blood cells of these patients. Targeted, small-molecule Jak inhibitors have also been used for treatment of rheumatoid arthritis. In cases of advanced melanoma, acquired resistance to PD-1 blockade drugs is associated with loss-of-functions of mutations in Jak1/2 genes. These mutations block interferon gamma signaling and prevent programmed death ligand 1 (PD-L1) expression in tumor cells.

DETAILS

App Id: FACS
Isotype: Rabbit IgG1k
Format Id: Conjugated
Clone Name: Jak1Y10221023-F11
Host Animal: Rabbit
Clonality Id: Monoclonal
Conjugate Id: APC
Reactivity Id: Human, Mouse
Product Content: 1X PBS, 0.09% NaN3, 0.2% BSA
Alternative Name: Tyrosine-protein kinase JAK1, Janus kinase 1
Application Note: For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells or 5 µL per 100 µL of staining volume. It is recommended that the reagent be titrated for optimal performance for each application. See product image legends for additional information.
Storage Condition: Store at 2-8°C. Avoid repeated freeze and thaw cycles.
Immunogen Information: A synthetic phospho-peptide corresponding to residues surrounding Tyr1022/1023 of human phospho-Jak1