mouse monoclonal IgG1; JFC1 Antibody (F-6) is an IgG1 κ mouse monoclonal JFC1 antibody that detects JFC1 of mouse, rat and human origin by WB, IP, IF and ELISA. JFC1 Antibody (F-6) is available as the non-conjugated anti-JFC1 antibody form, as well as multiple conjugated forms of anti-JFC1 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Synaptotagmins, rabphilin-3A and DOC2 belong to a family of C-terminal type (C-type) tandem C2 proteins and are involved in vesicular trafficking. JFC1, also designated Slp1 (for synaptotagmin-like protein), belongs to a unique family of C-type tandem C2 proteins designated Slp. JFC1 contains two N-terminal Slp homology comains (SHD), which each comprise two conserved α-helical regions, desigated SHD1 and SHD2. SHD1 and SHD2 specifically and directly bind the GTP-bound form of Rab 27a. JFC1 also binds phosphatidylinositol 3,4,5-triphosphate-binding ATPase. JFC1 is transcriptionally activated by NFκB and upregulated by TNFα in prostate carcinoma cells. JFC1 associates with the plasma membrane.

Free sample available. Limit 3 free samples for each full size Santa Cruz Biotechnology primary antibody ordered. All samples must be different. Customer responsible for shipping costs.