1164899-10mg 1164899-1mg
IDE1
Biogems
DESCRIPTION
IDE1 activates the TGF-beta signaling pathway and induces definitive endoderm formation in human and mouse embryonic stem cells. It is also reported to increase the levels of Nodal expression, induce Smad2 phosphorylation and SOX17 expression.
DETAILS
- Purity: ≥98%
- Synonyms: 1DE 1, Inducer of Definitive Endoderm 1
- Cas Number: 1160927-48-9
- References: Hoveizi, E., Nabiuni, M., Parivar, K., Ai, J., & Massumi, M. (2014). Definitive endoderm differentiation of human‐induced pluripotent stem cells using signaling molecules and IDE1 in three‐dimensional polymer scaffold. Journal of Biomedical Materials Research Part A, 102(11), 4027-4036. Borowiak, M., Maehr, R., Chen, S., Chen, A. E., Tang, W., Fox, J. L., ... & Melton, D. A. (2009). Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells. Cell stem cell, 4(4), 348-358.Aguayo-Mazzucato, C., & Bonner-Weir, S. (2010). Stem cell therapy for type 1 diabetes mellitus. Nature Reviews Endocrinology, 6(3), 139-148.
- Application: FA
- Formulation: Crystalline solid
- Chemical Name: 1-[2-[(2-carboxyphenyl)methylene]hydrazide]-heptanedioic acid
- Molecular Weight: 306.3
- Molecular Formula: C15H18N2O5
- Storage Conditions: Product should be kept at -20°C.
- Pubchem Openeye Can Smiles: C1=CC=C(C(=C1)C=NNC(=O)CCCCCC(=O)O)C(=O)O