mouse monoclonal IgG2b; mtTFA Antibody (F-6) is an IgG2b κ mouse monoclonal mtTFA antibody (also designated TFAM antibody, MtTf1 antibody, TCF6 antibody, or TCF6L2 antibody) that detects the mtTFA protein of mouse, rat and human origin by WB, IP, IF and ELISA. mtTFA Antibody (F-6) is available as both the non-conjugated anti-mtTFA antibody form, as well as multiple conjugated forms of anti-mtTFA antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. mtTFA (mitochondrial transcription factor A), also known as mtTF1, TFAM, TCF6 (for transcription factor 6-like1), TCF6L2 and tsHMG, is a nuclear-encoded gene product that is imported into the mitochondria. mtTFA is required for many aspects of mitochondrial biogenesis including the replication and transcription of mitochondrial DNA (mtDNA). In mouse, testis-specific mtTFA is missing the mitochondria targeting sequence and is present in the nucleus rather than the mitochondria. This form of mtTFA is located primarily in the nuclei of elongated spermatids and may be involved in the regulation of gene expression of the haploid male genome. During mouse and human spermatogenesis there is a reduction of mtTFA protein levels and a reduction in mtDNA copy number. These features may provide one of the mechanisms by which paternal mtDNA transmission is prevented. mtTFA has been associated with mitochondrial disorder in humans characterized by ocular myopathy, exercise intolerance and muscle wasting.