mouse monoclonal IgG2a; SH2D4A Antibody (F-5) is an IgG2a κ mouse monoclonal SH2D4A antibody (also designated SH2D4A antibody) that detects the SH2D4A protein of human origin by WB, IP, IF and ELISA. SH2D4A Antibody (F-5) is available as both the non-conjugated anti-SH2D4A antibody form, as well as multiple conjugated forms of anti-SH2D4A antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. SH2D4A (SH2 domain containing protein 4A), also known as SH2A, is a ubiquitously expressed 454 amino acid docking protein that belongs to the SH2 signaling protein family. Members of this family typically participate in intracellular signaling. Localizing to the cytoplasm, SH2D4A contains one Src homology 2 (SH2) domain. SH2 domains bind to tyrosine-phosphorylated regions of target proteins, frequently linking activated growth factors to putative signal transduction proteins. This suggests that SH2D4A, via its SH2 domain, may play an important function in cellular signal transduction. More specifically, SH2D4A is believed to function as an inhibiting factor in PKC signal transduction. In addition, SH2D4A exhibits abnormal expression in various cancers, implying that it may be involved in tumorigenesis.

Free sample available. Limit 3 free samples for each full size Santa Cruz Biotechnology primary antibody ordered. All samples must be different. Customer responsible for shipping costs.