Saxagliptin (hydrochloride)

DESCRIPTION

A potent DPP-4 inhibitor (Ki = 0.6 nM); inhibits DPP-4 ex vivo (ED50 = 0.12 μmol/kg) in plasma from normal fasted rats; reduces plasma glucose levels in Zuckerfa/fa diabetic rats in a dose-dependent manner when administered orally in doses ranging from 0.3-3 mg/kg; increases plasma insulin levels and improves glucose clearance in ob/ob mice; induces systolic and diastolic dysfunction, reduces contractile force, and exacerbates ischemia-reperfusion injury-induced cardiac dysfunction in isolated guinea pig hearts

DETAILS

Inchi: InChI=1S/C18H25N3O2.ClH/c19-8-13-2-12-3-14(12)21(13)16(22)15(20)17-4-10-1-11(5-17)7-18(23,6-10)9-17;/h10-15,23H,1-7,9,20H2;1H/t10-,11+,12-,13?,14+,15-,17+,18-;/m1./s1
Purity: ≥98%
Raptas: Product Type|Biochemicals|Small Molecule Inhibitors|Peptidases & Proteases||Research Area|Cardiovascular System|Cardiovascular Diseases|Myocardial Infarction||Research Area|Cardiovascular System|Heart|Myocardial Contractility||Research Area|Cell Biology|Proteolysis|Cytosolic & Secreted Proteases||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Obesity
Smiles: O=C(N1[C@H](C#N)C[C@H]2[C@@H]1C2)[C@H]([C@@]3(C[C@H](C4)C5)C[C@H]5C[C@@]4(O)C3)N.Cl
Inchikey: TUAZNHHHYVBVBR-WYHYZCDFSA-N
Cas Number: 709031-78-7
Formulation: A crystalline solid
Storage Temp: -20
Shipping Temp: -20
Formula Markup: C18H25N3O2 • HCl
Formula Weight: 351.9
Shelf Life Days: 1460