CEACAM5 CHO Cell Line (Medium Expression)

DESCRIPTION

Recombinant clonal CHO cell line stably expressing full-length human CEACAM5 (NM_004363). Surface expression of CEACAM5 was confirmed by flow cytometry. The stable clonal cell line was selected for different levels of CEACAM5 expression (High, Medium, and Low) compared to the parental CHO-K1 cell line.

DETAILS

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Uniprot: P06731
Shiptemp: -80°C (dry ice)
Synonyms: Carcinoembryonic antigen-related cell adhesion molecule 5, Carcinoembryonic antigen (CEA), Meconium antigen 100, CD66e, CEA
Warnings: Avoid freeze/thaw cycles
Category: Cell Signaling Pathway/Cell Line
Background: Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5, also known as CD66e) is a cell surface glycoprotein that serves as a cell adhesion protein. It has been used as a clinical biomarker to detect liver metastasis from gastrointestinal cancers and to predict gastrointestinal cancer relapse. CEACAM5 was recently identified as a potential target antigen for CAR T-cell therapy. Additionally, CEACAM5 may be involved in the inhibition of cell differentiation, apoptosis, and cell polarity.
Description: Recombinant clonal CHO cell line stably expressing full-length human CEACAM5 (NM_004363). Surface expression of CEACAM5 was confirmed by flow cytometry. The stable clonal cell line was selected for different levels of CEACAM5 expression (High, Medium, and Low) compared to the parental CHO-K1 cell line.
Supplied As: Each vial contains 2 x 106 cells in 1 ml of cell freezing medium (BPS Bioscience #79796)
Unspsc Code: 41106514
Unspsc Name: Stable mammalian cell lines
Applications: • Screen and validate antibodies against CEACAM5 for drug discovery and research. • Screen for compounds that regulate or inhibit CEACAM5 signaling in a cellular context. • Perform binding assays to screen for potential CEACAM5 ligands.
Host Species: hamster
Product Type: Cell Line
Host Cell Line: CHO-K1 cells, Chinese Hamster Ovary, epithelial-like cells, adherent
Biosafety Level: BSL-1
Related Products: 100509, 78719, 78720
Storage Stability: Cells are shipped in dry ice and should immediately be thawed or stored in liquid nitrogen upon receipt. Do not use a -80°C freezer for long term storage.
Mycoplasma Testing: The cell line has been screened to confirm the absence of Mycoplasma species.
Scientific Category: Cell Signaling Pathway
Required Accessories: 60186,79974,79796
Signed License Required: Yes