G-CSF, Human

DESCRIPTION

Granulocyte Colony-Stimulating Factor (G-CSF) contains internal disulfide bonds. Among the family of colony-stimulating factors, Granulocyte Colony Stimulating Factor (G-CSF) is the most potent inducer of terminal differentiation to granulocytes and macrophages of leukemic myeloid cell lines. The synthesis of Granulocyte Colony Stimulating Factor (G-CSF) can be induced by bacterial endotoxins, TNF, Interleukin-1 and GM-CSF. Prostaglandin E2 inhibits the synthesis of Granulocyte Colony Stimulating Factor (G-CSF). In epithelial, endothelial, and fibroblastic cells secretion of Granulocyte Colony Stimulating Factor (G-CSF) is induced by Interleukin-17.

DETAILS

Form: Lyophilized
Purity: > 95% as analyzed by SDS-PAGE> 95% as analyzed by HPLC
Species: Human
Product Line: Growth Factors
Expression System: E. coli
Storage Stability: Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles.
Biological Activity: ED50 < 0.1 ng/ml, measured by a cell proliferation assay of M-NFS-60 cells, corresponding to a specific activity of > 1.0 × 107 IU/mg.
Protein Construction: Expressed with an N-terminal Met. G-CSF (Thr27-Pro200)\nAccession # Q8N4W3