RP01520
Recombinant Human MITF Protein
ABclonal
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DESCRIPTION
Microphthalmia-associated transcription factor (MITF) is a member of the basic helix-loop-helix leucine zipper (bHLH-Zip) family and functions as the master regulator of the melanocytic lineage.MITF (Microphthalmia-associated transcription factor) is a lineage-specific transcription factor that plays a critical role in melanocyte homeostasis and whose deregulation has been shown to contribute to melanoma disease. Microphthalmia-associated transcription factor (MITF) is expressed in melanomas and has a critical role in melanocyte development and transformation. Because inhibition of MITF inhibits cell growth in melanoma, MITF is a potential therapeutic target molecule. Microphthalmia-associated transcription factor (MITF) regulates the transcription of its target genes by binding to their promoters. Microphthalmia-associated transcription factor (MITF) is a key regulator of differentiation of melanocytes and retinal pigment epithelial cells, but it also has functions in non-pigment cells.
DETAILS
- Tag: N-raFc
- Source: HEK293 cells
- Gene Id: 4286
- Species: Human
- Lead Time: 3-5 weekdays
- Swiss Prot: O75030
- Research Areas: Other Recombinant Protein
- Alternative Names: CMM8, COMMAD, MI, WS2, WS2A, bHLHe32,MITF,COMMAD,MI,WS2,WS2A,bHLHe32
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