T36464
Caylin-1
TargetMol
DESCRIPTION
Nutlin-3 is an activator of p53 that functions by inhibiting the interaction of p53 with MDM2, a negative regulator of p53 activity. Caylin-1 is a nutlin-3 analog which contains chlorine substituents at the 3 and 4 positions on two of the phenyl rings rather than a single 4-chloro as seen in nutlin-3. At high concentrations, caylin-1 inhibits the growth of HCT116 cells with an IC50 value of approximately 7 μM, making it about 7-fold less potent than nutlin-3 in the same assay. Interestingly, at concentrations at or below 1 μM, caylin-1 promotes the growth of HCT116 cells approximately 20% compared to untreated cells. The mechanism of the growth promoting properties of caylin-1 have not yet been elucidated.
DETAILS
- Cas: 1207480-88-3
- Purity: 98%
- Smiles: C(=O)(N1[C@H]([C@H](N=C1C2=C(OC(C)C)C=C(OC)C=C2)C3=CC(Cl)=C(Cl)C=C3)C4=CC(Cl)=C(Cl)C=C4)N5CC(=O)NCC5
- Category: Compound
- Molecular Weight: 650.38
- Molecular Formula: C30H28Cl4N4O4
Lead Time: Please Inquire
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