mouse monoclonal IgG1; Islet-1 Antibody (B-1) is an IgG1 κ mouse monoclonal Islet-1 antibody (also designated ISL LIM Homeobox 1 antibody, Insulin Gene Enhancer Protein ISL-1 antibody, Islet-1 antibody, ISLET1 antibody, Isl-1 Transcription Factor LIM/Homeodomain (Islet-1) or ISL1 Transcription Factor LIM/Homeodomain antibody) that detects the Islet-1 protein of mouse, rat and human origin by WB, IP, IF and ELISA. Islet-1 Antibody (B-1) is available as both the non-conjugated anti-Islet-1 antibody form, as well as multiple conjugated forms of anti-Islet-1 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Islet-1 (ISL1 transcription factor, LIM/homeodomain) and Islet-2 (ISL2 transcription factor, LIM/homeodomain) contain amino-terminal LIM domains and a carboxy-terminal homeodomain and both influence developmental events. Islet-1 influences embryogenesis of the pancreatic islets of Langerhans and neural tube motor neuron differentiation. In developing mouse teeth, Islet-1 mediates patterning of dentition as an activator of Bmp4 expression in incisor (distal) areas of the stomatodeal epithelium. Islet-1 expression defines cardiac progenitor cell populations and is required for normal cardiac development and asymmetry. Islet-2 activity in newly generated motor neurons permits the diversification of visceral and somatic motor neuron subtypes in the developing spinal cord. Murine Islet-2 specifies retinal ganglion cell (RGC) laterality by repressing an ipsilateral pathfinding program unique to the ventral-temporal crescent (VTC) of RGCs in a Zic2- and EphB1-dependent manner.

Free sample available. Limit 3 free samples for each full size Santa Cruz Biotechnology primary antibody ordered. All samples must be different. Customer responsible for shipping costs.