Bevantolol (hydrochloride)

DESCRIPTION

A β1-AR antagonist (Ki = 14.79 nM in rat cortical membranes); selective for β1- over β2-ARs (Ki = 588.84 nM), as well as α2-ARs up to 100 μM, but is an antagonist of α1-ARs (Ki = 125.89 nM); inhibits LVA-ICa in dissociated rat ventro-medial hypothalamic neurons (IC50 = 40 μM); inhibits norepinephrine-induced contraction of isolated rabbit thoracic aorta (pA2 = 4.77), isoprenaline-induced inotropic effects in isolated guinea pig right atria (pA2 = 7.74), and isoprenaline-induce relaxation of isolated guinea pig trachea (pA2 = 6.69); prevents immobilization stress-induced increases in systolic blood pressure in a rat model of stress-induced hypertension at 250 mg/kg per day

DETAILS

Inchi: InChI=1S/C20H27NO4.ClH/c1-15-5-4-6-18(11-15)25-14-17(22)13-21-10-9-16-7-8-19(23-2)20(12-16)24-3;/h4-8,11-12,17,21-22H,9-10,13-14H2,1-3H3;1H
Purity: ≥98%
Raptas: Product Type|Biochemicals|Ion Channel Modulation|Blockers||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Cardiovascular System|Heart|Arrhythmia||Research Area|Cardiovascular System|Vasculature|Vasodilation
Smiles: CC1=CC=CC(OCC(O)CNCCC2=CC(OC)=C(OC)C=C2)=C1.Cl
Inchikey: FJTKCFSPYUMXJB-UHFFFAOYSA-N
Cas Number: 42864-78-8
Formulation: A crystalline solid
Storage Temp: -20
Shipping Temp: -20
Formula Markup: C20H27NO4 • HCl
Formula Weight: 381.9
Shelf Life Days: 1460