BAN ORL 24 (hydrochloride)

DESCRIPTION

A NOP receptor antagonist (Ki = 0.24 nM in a radioligand binding assay using CHO cell membranes expressing the human receptor); selective for NOP receptors over μ-, δ-, and κ-opioid receptors (Kis = 0.19, 0.34, and >1 µM, respectively); reduces NOP-induced GTPγS binding (pA2 = 9.98) and calcium mobilization (KB = 0.93 nM) in CHO cells; inhibits electrically induced twitches in isolated mouse and rat vas deferens, as well as isolated guinea pig ileum, at 100 nM; reverses BPR1M97-induced thermal and mechanical antinociceptive activities in mice

DETAILS

Inchi: InChI=1S/C27H35N3O2.2ClH/c31-26(25-12-6-17-30(25)20-22-8-2-1-3-9-22)28-15-7-16-29-18-13-27(14-19-29)24-11-5-4-10-23(24)21-32-27;;/h1-5,8-11,25H,6-7,12-21H2,(H,28,31);2*1H/t25-;;/m1../s1
Purity: ≥95%
Raptas: Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Neuroscience|Pain Research
Smiles: O=C([C@@H]1N(CC2=CC=CC=C2)CCC1)NCCCN3CCC4(OCC5=CC=CC=C54)CC3.Cl.Cl
Inchikey: NEEVITHVDIQNJY-KHZPMNTOSA-N
Cas Number: 1401463-54-4
Formulation: A solid
Storage Temp: -20
Shipping Temp: -20
Formula Markup: C27H35N3O2 • 2HCl
Formula Weight: 506.5
Shelf Life Days: 1460