Mouse DPPIV / CD26 Protein, His Tag, active dimer (active enzyme, MALS verified)

DESCRIPTION

Dipeptidyl peptidase-IV (DPPIV) is also known as adenosine deaminase complexing protein 2, DPPIV or CD26 is antigenic enzyme expressed on the surface of most cell types and is associated with immune regulation, signal transduction and apoptosis. It is an intrinsic membrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. The substrates of DPPIV are proline (or alanine)-containing peptides and include growth factors, chemokines, neuropeptides, and vasoactive peptides. DPPIV plays a major role in glucose metabolism. It is responsible for the degradation of incretins such as GLP-1. DPPIV plays an important role in tumor biology, and is useful as a marker for various cancers, with its levels either on the cell surface or in the serum increased in some neoplasms and decreased in others. DPPIV also binds the enzyme adenosine deaminase specifically and with high affinity. The significance of this interaction has yet to be established.

DETAILS

Tag: C-10×His
Host: HEK293
Size: 50ug
Buffer: 20 mM Tris, 150 mM NaCl, pH8.0
Format: Powder
Purity: 95%
Source: Mouse DPPIV, His Tag (DP4-M52H5) is expressed from human 293 cells (HEK293). It contains AA Ser 29 - His 760 (Accession # P28843-1).
Storage: -20℃
Category: Enzymes
Molecule: DPPIV
Accession: NP_034204.1
Conjugate: Unconjugated
Stability: ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Exp Region: Ser 29 - His 760
Swiss-prot: P28843-1
Package Size: 50ug*1
Characteristics: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 86.4 kDa. The protein migrates as 110-120 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level: 1.0 EU per μg
Molecular Weight: 86.4 kDa
Shipping Condition: RT
Species Reactivity: Mouse
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