Skip to Main Content
Welcome to the Marketplace

Go to Main Navigation

GLE-H52H3-20ug GLE-H52H3-100ug GLE-H52H3-1mg

Human Glucosylceramidase Protein, His Tag



  • Tag: C-10×His
  • Host: HEK293
  • Size: 20ug
  • Buffer: 0.1 M Sodium Citrate, 1 mM TCEP, pH5.5
  • Format: Liquid
  • Purity: 90%
  • Storage: -70℃
  • Category: Enzymes
  • Molecule: Glucosylceramidase
  • Accession: NP_001005741.1
  • Conjugate: Unconjugated
  • Stability: ● The product MUST be stored at -70°C or lower upon receipt; ● -70°C for 3 months under sterile conditions.
  • Background: Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose. Thereby, it plays a central role in the degradation of complex lipids and the turnover of cellular membranes. Through the production of ceramides,it participates in the PKC-activated salvage pathway of ceramide formation and plays a role in cholesterol metabolism. It may either catalyze the glucosylation of cholesterol, through a transglucosylation reaction that transfers glucose from glucosylceramide to cholesterol. Defects in Glucosylceramidase are the cause of Gaucher disease, also known as glucocerebrosidase deficiency. Gaucher disease is the most prevalent lysosomal storage disease, characterized by accumulation of glucosylceramide in the reticulo-endothelial system. Currently, enzyme replacement therapy is used to treat patients with the disease.
  • Exp Region: Ala 40 - Gln 536
  • Swiss-prot: P04062-1
  • Characteristics: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 57.5 kDa. The protein migrates as 60-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
  • Endotoxin Level: 1.0 EU per μg
  • Molecular Weight: 57.5 kDa
  • Shipping Condition: Dry ice
  • Species Reactivity: Human
  • Extra Shippinghandling Fee: Please see 'Shipping-and-Payments' sheet. Website:


Human Glucosylceramidase, His Tag (GLE-H52H3) is expressed from human 293 cells (HEK293). It contains AA Ala 40 - Gln 536 (Accession # P04062-1).