E0630Hu
Human Dickkopf-1, DKK1 ELISA Kit
Bioassay Technology Laboratory
DESCRIPTION
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6 (PubMed: 22000856). DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (PubMed: 17143291). Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity (By similarity).
DETAILS
- GeneID: 22943
- Species: Human
- Storage: 2-8ºC
- MASS(Da): 28,672
- Synonyms: Dickkopf-1;Dickkopf-related protein 1;DKK 1;DKK1;Dkk-1;hDkk-1;SK
- Assay Time: 1h 30m
- Assay Type: Sandwich
- Gene Names: DKK1
- Reactivity: Human
- Sample Type: Serum, plasma, cell culture supernates
- Sensitivity: 0.26ng/ml
- Target Protein: DKK1
- Detection Range: 0.5-150ng/ml
- Full Product Name: Dickkopf-1
- Standard Solution: 160ng/ml
- UniProt Accession: O94907