RP01613
Recombinant Human CCL1/I-309 Protein
ABclonal
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DESCRIPTION
CCL1 or chemokine (C-C motif) ligand 1, also known as I-309 or TCA-3, is a member of the chemokine (C-C motif) ligand family. The C-C chemokines have two cysteines nearby the amino terminus. There have been at least 27 distinct members of this subgroup reported for mammals, called C-C chemokine ligands (CCL)-1 to 28. I-309/CCL1/TCA-3 interacts with the G protein-linked transmembrane chemokine receptors CCR8 and induces biochemical events that may result in the control of chemotaxis, proliferation, apoptosis and adhesion. It has been demonstrated that I-309/CCL1/TCA-3 displays chemotactic activity for monocytes and other cell types such as NK cells and dendritic cells, but not for neutrophils. Furthermore, as the only known physiological ligand for CCR8, I-309/CCL1/TCA-3 was identified as a potent inhibitor of HIV-1 envelope-mediated cell-cell fusion and virus infection. I-309/CCL1/TCA-3 induces significant levels of LTC4 from elicited eosinophils.
DETAILS
- Tag: No tag
- Source: Pichia
- Gene Id: 6346
- Species: Human
- Lead Time: 3-5 weekdays
- Swiss Prot: P22362
- Research Areas: Cytokines & Cytokine receptors
- Alternative Names: CCL1,I-309,P500,SCYA1,SISe,TCA3
Equivalent Items
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