AZ 505

DESCRIPTION

An inhibitor of SMYD2 (IC50 = 0.12 μM); selective for SMYD2 over SMYD3, DOT1L, EZH2, GLP, G9A, and SET7/9 (IC50s = >83.3 μM); delays cyst growth in early- and late-stage Pdk1 conditional knockout mouse models of polycystic kidney disease at 10 mg/kg

DETAILS

Inchi: InChI=1S/C29H38Cl2N4O4/c30-23-8-6-20(18-24(23)31)10-13-32-15-12-27(38)35(22-4-2-1-3-5-22)17-16-33-14-11-21-7-9-25(36)28-29(21)39-19-26(37)34-28/h6-9,18,22,32-33,36H,1-5,10-17,19H2,(H,34,37)
Purity: ≥95%
Raptas: Product Type|Biochemicals|Small Molecule Inhibitors|Methyltransferases||Research Area|Epigenetics, Transcription, & Translation|Writers|Histone Methylation
Smiles: O=C1COC2=C(CCNCCN(C3CCCCC3)C(CCNCCC4=CC(Cl)=C(Cl)C=C4)=O)C=CC(O)=C2N1
Inchikey: LIBVHXXKHSODII-UHFFFAOYSA-N
Cas Number: 1035227-43-0
Formulation: A crystalline solid
Storage Temp: -20
Shipping Temp: -20
Formula Markup: C29H38Cl2N4O4
Formula Weight: 577.6
Shelf Life Days: 1460