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HY-W457950

Thalidomide-5-propargyl

MedChem Express

- Open Babel Depiction O O O N H O N CH O

DESCRIPTION

Thalidomide-5-propargyl is a propargyl-modified Thalidomide (HY-14658), that acts as a Cereblon ligand to recruit CRBN proteins. Thalidomide-5-propargyl use alkynyl group at the end to be directly used in the synthesis of triazoles in the synthesis of PROTAC molecules, and is a key intermediate in the synthesis of PROTAC molecules based on CRBN design[1].

DETAILS

  • Purity: >98%
  • Smiles: O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC(OCC#C)=C3)=O
  • Category: Reference compound
  • Lead Time: 1-2 days
  • Cas Number: 2226303-74-6
  • Molecular Weight: 312.28
  • Molecular Formula: C16H12N2O5

Lead Time: < 1 week

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