HY-W457950
Thalidomide-5-propargyl
MedChem Express
DESCRIPTION
Thalidomide-5-propargyl is a propargyl-modified Thalidomide (HY-14658), that acts as a Cereblon ligand to recruit CRBN proteins. Thalidomide-5-propargyl use alkynyl group at the end to be directly used in the synthesis of triazoles in the synthesis of PROTAC molecules, and is a key intermediate in the synthesis of PROTAC molecules based on CRBN design[1].
DETAILS
- Purity: >98%
- Smiles: O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC(OCC#C)=C3)=O
- Category: Reference compound
- Lead Time: 1-2 days
- Cas Number: 2226303-74-6
- Molecular Weight: 312.28
- Molecular Formula: C16H12N2O5
Lead Time: < 1 week
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