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Z03052-10

Scientist.com Supplier

IL-11, Mouse(HEK 293-expressed)

GenScript

DESCRIPTION

Interleukin-11 (IL-11) is a pleiotropic cytokine that was originally detected in the conditioned medium of an IL-1α-stimulated primate bone marrow stromal cell line (PU-34) as a mitogen for the IL-6-responsive mouse plasmacytoma cell line T11. IL-11 contains no cysteine residues or potential glycosylation sites. IL-11 has multiple effects on both hematopoietic and nonhematopoietic cells. Many of the biological effects described for IL-11 overlap those for IL-6. In vitro, IL-11 can synergize with IL-3, IL-4 and SCF to shorten the G0 period of early hematopoietic progenitors. IL-11 also enhances the IL-3-dependent megakaryocyte colony formation. IL-11 has been found to stimulate the T cell dependent development of specific immunoglobulin-secreting B cell.

DETAILS

  • Form: Lyophilized
  • Purity: > 95% as analyzed by SDS-PAGE> 95% as analyzed by HPLC
  • Species: Mouse
  • Product Line: Cytokines
  • Expression System: HEK 293
  • Storage Stability: Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles.
  • Biological Activity: ED50 < 3.0 ng/ml, measured in a cell proliferation assay using TF-1 cells.
  • Protein Construction: IL-11 (Gly23-Leu199)\nAccession # P47873