36-1898
Monoclonal Antibody to CD22 / BL-CAM(Clone : MYG13)
Abeomics
DESCRIPTION
Recognizes a protein of 130-140kDa, identified as CD22 (also known as BL-CAM). CD22 expression is restricted to normal and neoplastic B cells and is absent from other haemopoietic cell types. In B-cell ontogeny, CD22 is first expressed in the cytoplasm of pro-B and pre-B cells, and on the surface as B cells mature to become IgD+. It is not expressed by plasma cells, CD22 is found highly expressed in follicular mantle and marginal zone B-cells, and while germinal center B-cells are relatively weak. CD22 is a member of the immunoglobulin superfamily and serves as an adhesion receptor for sialic acid-bearing ligands expressed on erythrocytes and all leukocyte classes. It also associates with tyrosine kinases and play a role in signal transduction and B-cell activation.
DETAILS
- Gene: CD22
- App Id: FACS
- Antigen: CD22 / BL-CAM
- Gene Id: 933
- Isotype: Mouse IgG1, kappa
- Format Id: Purified
- Clone Name: MYG13
- Uniprot Id: P20273
- Host Animal: Mouse
- Clonality Id: Monoclonal
- Purification: Affinity Chromatography
- Reactivity Id: Rat, Mouse, Human
- Product Content: 100 µg in 500 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
- Alternative Name: CD22||SIGLEC2
- Application Note: Flow Cytometry (1-2ug/million cells),
- Storage Condition: Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.
- Immunogen Information: Human Raji cells
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