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Bellen Chemistry

Scientist on July 9, 2024

This installment of Suppler Spotlight® highlights Bellen Chemistry, an integrated Contract Chemistry Service Organization(CCSO) with years of accumulated technical advantages and experiences in chemical synthesis of small molecule compounds.

What is your company’s mission?

At Bellen our mission is to be your first-choice service provider for contract chemistry services in the small molecules field whilst maintaining our key values of customer focus, continuous improvement, reliability, integrity and sustainability.

What products and services do you offer?

Bellen are a Contract Chemistry Service Organisation (CCSO) specializing in the drug substance small molecules field. Our services range from discovery through to development and manufacturing.

Our CRO service focuses on providing chemistry services globally to early pre-clinical stage pharma and biotechs via FTE and FFS modes. Bellen specializes in the synthesis of novel, complex and challenging small molecule compounds to accelerate your new drug discovery programs.

Our CDMO operation focuses on delivering chemistry solutions tailored to suit different stages of your program needs, providing process development and manufacturing services for small molecule APIs, intermediates and regulatory starting materials (RSMs).

What problems do you solve?

At Bellen, we love chemistry problems! With a highly trained and experienced technical team with access to specialized platforms and varied infrastructure, no chemistry problem is too big or small for us. Our clients would class us as their go-to partner for custom synthesis and manufacturing. If there’s one area where we see our partners contact us time and time again, it’s during the first scale-up of their assets, with a 120-person strong process development team we specialize in delivering effective, robust and scalable routes of production in a timely manner.

What are the most innovative tools and technologies that you offer?

At Bellen, we value and promote continuous learning, exploring and practicing new technologies to ensure our team and organization keep abreast of industrial trends. Our current technological capabilities, listed below, help create more efficient pathways for scale-up of complex chemistry from lab to commercial scale.

Biocatalysis Chemistry Platform – 500+ Enzymes in library
Metal Catalyst Screening – 350+ Metal & Ligand Library
Flow Chemistry – lab and manufacturing scale
Photo Chemistry - 2L (200-1000W) and 100L (3000W) reactors
Crystallisation platform – Polymorph, Salt Screening and Crystallisation development

Stay in touch to keep up to date with new technologies we introduce to our portfolio.

What are your competitive advantages?

We consistently deliver projects on time, in full and within specification. We are recognized by our customers as being enthusiastic, responsive, flexible and cost-effective in providing chemistry solutions. Our stats speak for themselves with >96% CRO projects and >97% CDMO projects successfully delivered over the last 5 years.

Alongside our technical expertise we are also well under way with our sustainability journey with recent recognition by EcoVadis as being within the top 35% of companies assessed. We are committed to the same goals as our clients of protecting our planet and contributing to sustainable and ethical practices across our operation.

Who are your clients?

We support global pharmaceutical companies, biotech innovators and new drug development institutions for their research programs from discovery to commercial stage through comprehensive chemistry solutions.

What new products and services are you developing in 2024?

This year has seen the introduction of our PROTAC related chemistry services. Bellen has assembled a growing team of 25 chemists with expertise in PROTAC technology. Our team has built a collection of E3 ligase ligands, linkers and several literature reported target-binding ligands. We possess rich experience in ligand structure modification, conjugation and all types of custom syntheses from mg to kg scale. Our services are supported with robust purification and analytical support for PROTAC featured compounds.

Bellen is continually improving and adding to our service offerings, with plans to introduce other exciting capabilities over the next couple of years.

Where are your laboratories and offices located?

Our chemistry infrastructure and HQ is based in China with sales offices around the world:
Beijing – HQ and R&D Centre
Shanghai – Process R&D Centre
Yantai – Manufacturing Plant
Sales offices – France, UK, Japan and USA (Boston and San Francisco)