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Safety Pharmacology

Assess the impact of a therapeutic for human use on vital organ systems before first-in-man drug testing.
Machine Learning/ AI

Predict and model an outcome (e.g. disease progression) based on input variables (i.e. features.)
Discovery Computational Systems Biology

Model the interaction of biological system with drug candidates.
Structural Chemistry

Examine the relationship between protein structure and function.
Drug Drug Interactions

Determine whether a substance affects the activity of a drug when both are administered together.
Cytochrome P450s

Assess the inhibition or induction of the various isozymes of cytochrome P450s by drug candidates.
Hepatocyte Toxicity

Assess the cytotoxic effects of pre-clinical compounds on hepatocytes purified from patients and animal models.
Metabolite Identification

Identify drug metabolites that are formed after administration of drug to an animal model or patient.
Human Organs-On-Chips

Use Organs-On-Chips for target identification and validation, target-based screening, and phenotypic screening.
Drug-Induced Liver Injury (DILI) Toxicity Assays

Use biochemical, cell-based or in vivo assays to measure toxicity from drug-induced liver injury.
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