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Wayne State University Karmanos Cancer Institute Pharmacology Core

Website:
karmanos.org/Pharm
Headquarters:
Detroit, Michigan, US
Company Type:
Academic Core Facility

The mission of the Pharmacology Core is to provide state-of-the-art analytical technology and a broad range of pharmacology expertise to enable evaluation of critical pharmacological endpoints in clinical trials and preclinical studies.

Core Services Available

The Pharmacology Core offers the following services based on fee-for-service:

Biospecimen Processing service provides a centralized resource for the acquisition, processing, and shipment of patient samples including blood, plasma, urine, peripheral blood mononuclear cell (PBMC), bone marrow, and tissue samples. All biospecimens are collected from patients who provided informed consent following an Institutional Review Board approved protocol. Specimen handling, processing, and shipment are in compliance with good laboratory practice (GLP) procedures, approved standard operating procedures, and regulatory requirements to ensure sample integrity and quality. A secure database that includes detailed information on the acquisition, processing, distribution of the samples along with related clinical data is maintained.
Bioanalysis service provides development, validation, and implementation of analytical methods using high or ultra-high performance liquid chromatography (HPLC or UPLC) coupled with tandem mass spectrometer (LC-MS/MS), ultraviolet, photodiode array, or fluorescence detector for quantitative measurement of drugs, metabolites, and endogenous compounds in biological samples (e.g., biofluid, tissue, or cell culture samples). Method validation is provided based on the United States Food and Drug Administration Guidance for Bioanalytical Method Validation to ensure that a particular method is specific, sensitive, reliable, reproducible, and suitable for the intended analytical use. Rigorous quality assurance and quality control are provided for measurements of clinical and preclinical samples.
LC-MS/MS based targeted metabolomics aims to measure predefined groups of metabolites that are involved in major metabolic pathways including carbohydrate, protein, and lipid metabolism, etc (Table 1). We strive to provide GLP-quality analytical service at competitive prices, and regularly customize assays to meet investigators’ needs. Our services spans from initial consultation for study design and sample collection, sample preparation, instrumental analysis, to final data analysis and interpretation.

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Wayne State University Karmanos Cancer Institute Pharmacology Core
4100 John R Detroit, Michigan, 48201 United States
Wayne State University Karmanos Cancer Institute Pharmacology Core
4100 John R Street Detroit, MI, 48201 United States

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