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Wayne State University Karmanos Cancer Institute Animal Model and Therapeutics Evaluation Core

Website:
karmanos.org/AmTec
Headquarters:
Detroit, Michigan, US
Company Type:
Academic Core Facility

Mission of the Core

The mission of the Animal Model and Therapeutics Evaluation Core (AMTEC) is to provide research support through collaboration or fee for service by

Distributing cancer models developed at Karmanos Cancer Institute
Conducting in vivo testing of novel therapeutics
Assisting investigators in many aspects of small animal research
AMTEC interfaces with appropriate cores for follow-up sample analysis.
Core Services Available

Cancer Models Developed in KCI
Provide KCI and external investigators with mouse cell lines, in vivo outgrowth and related biological samples.
BALB/c mammary tumor panels with defined in vivo growth properties, MMTV induced tumor panel – 66, 67, 68H, 168, 4.10, 4T07, Hormone induced tumor panel – D2.1, D2A1, D2F2
Carcinogen induced mouse tumor lines with defined in vivo drug sensitivity profiles – mammary, colon and pancreatic lines
Coordinate with Translational Research Core to provide xenografts of primary tumors and human cell lines such as MCF7, MCF10 series and MCF12 series
in vivo Testing of Novel Therapeutics
Pre-clinical testing of experimental therapeutics
Generate documents for publication, grant/contract application and intellectual property application
Generate new drug resistant or genetically targeted tumor lines
Generate new xenograft models from human tissues
Assist Investigators in All Aspects of Small Animal Research
Preparation of Animal Investigation Protocols for WSU, Funding Agencies and Regulatory Agencies
Breeding and genotyping of genetically modified animals
Small animal whole body Irradiation, surgery, tissue collection
Train lab personnel for specialized techniques
Provide consultation to generate genetically modified mouse strains

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Wayne State University Karmanos Cancer Institute Animal Model and Therapeutics Evaluation Core
4100 John R Street Detroit, MI, 48201 United States
Wayne State University Karmanos Cancer Institute Animal Model and Therapeutics Evaluation Core
4100 John R Detroit, Michigan, 48201 United States

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