This core assists investigators in the Cancer Center with the generation of manipulated murine ES cells used to make sophisticated mouse models of human diseases, including cancer. These altered ES cells help us to understand how both individual genes and mutations work to cause cancer.

The Murine Embryonic Stem Cell Core has been created to help you make mutations in mouse embryonic stem cells. The core has several missions including: development of state-of-the art reagents for the production of targeted mutations in embryonic stem cells, the creation of quality-controlled embryonic stem cell lines, and the teaching of methods for embryonic stem cell culture and manipulation. The core provides seven different embryonic stem cell lines for the WUMS research community. In addition, this core provides a teaching service, so that ‘hands-on’ production of targeted ES clones can be learned. Finally, the core will arrange additional services for your ES clones such as karyotyping, MAP testing, and blastocyst injections. By providing a comprehensive service, we hope to facilitate the production of gain-of-function and loss-of-function mouse models for our faculty.​