Genetically engineered mouse models are indispensible tools for studying the function of specific genes and their roles in cancer. The Transgenic Animal Core at Science Park assists investigators in the development and use of genetically engineered mouse models. Since 1996, the core has produced over 175 unique mouse models using traditional transgenic methods as well as zinc-finger nucleases and the current state-of-the-art CRISPR/Cas9 system. These methods allow us to generate transgenic models as well as gene-targeted knock-out and knock-in models at low cost.

Science Park – Smithville
Services

Generation of transgenic mouse founders by pronuclear injection
Generation of gene-targeted knockout and knock-in mouse lines using zinc finger nucleases or CRISPR/Cas9 technologies
Re-derivation of specialized mouse lines via embryo transfer or in vitro fertilization using sperm
Cryopreservation of mouse embryos and sperm for archival storage
Consultation, technical support and training to investigators wishing to establish genetically modified animals