All investigators interested in performing a High Throughput or a High content siRNA screen will be invited to a preliminary meeting with the staff of the screening service. During this meeting all essential details regarding the screen will be discussed including cell lines, assay design, standard operating procedure of a screen, time line, cost and cell culture models. We currently have the capability of performing high throughput screens in utilizing both 2D monolayer cell culture models and 3D spheroid cell culture models.