The Bone Histomorphometry Core Laboratory provides histomorphometric analyses of non-decalcified bone specimens, including processing mouse bone specimens for non-decalcified histology and performing static and dynamic histomorphometric analyses of mouse bone specimens. The service is performed on a subsidized fee-for-service basis.

The function of the Bone Histomorphometry core is to perform histomorphometric analyses of non-decalcified bone specimens.

Processing mouse bone specimen for non-decalcified histology. Fixed and partially dehydrated mouse skeleton is provided by project investigators to the Core. These samples are embedded in plastic medium, sectioned and stained. Contact Michael Starbuck, mwstarbu@mdanderson.org, for more information on the protocol for proper sample preparation.

Performing static and dynamic histomorphometric analyses of mouse bone specimen. Using the Osteomeasure analytic system and the Bioquant Osteo II system, static parameters such as bone volume, trabecular number and cell counts as well as dynamic parameters of bone formation such as mineral apposition rates are quantified on non-decalcified bone sections. The core provides investigators with the data and will help them in evaluating their biological relevance.
About Bone Histomorphometry Core Laboratory

Purpose
To provide the faculty affiliated with the Bone Disease Program of Texas with high quality bone histomorphometry processing; analysis of the skeleton of genetically modified mice and tumor-bearing bones, and micro-CT analysis of bone specimens.