The University of Pennsylvania, via a $1 million GOALI grant from the NSF, has developed a center for microscale high throughput experimentation (HTE), using state-of-the-art facilities to develop novel methods or solve difficult transformations in an efficient, cost effective manner.

Here at UPenn we utilize parallel microscale high throughput experimentation (HTE), allowing for general reactions to be run at 10 µmol or 2.5 µmol in 1 mL or 250 µL reactor vials, with 1 mL vials as standard. Running reactions at 1/8th or 1/32th normal reaction scale delivers the ability to cut down on the amount of valuable substrate needed to find the optimum conditions.

The service center makes use of Virscidian™ Analytical Studio Express, allowing fast data processing and efficient data handling. With the added ability of remote access to HPLC/LCMS raw data, project collaboration and project updates become effortless.

Facility

• State-of-the-art laboratory design and equipment make for effortless reaction setup.
• Temperature ranges from -20 up to 200 °C
• Nitrogen / argon atmosphers
• Hydrogen / oxygen atmospheres from 1-500psi

Cutting edge catalysts, an extensive compound collection, and a comprehensive anhydrous solvent list make for rapid screen preparation