A Biospecimen Repository (BR) has been established to house biosamples and associated clinical and other data from participating study sites investigating TBI. Samples will be in the form of frozen human biological specimens. Data will be stored in electronic form and will consist of de-identified clinical history, neuroimaging findings, and laboratory data. Current protocols permit the holding in the BR of whole blood, plasma, serum and white blood cells obtained from TBI subjects and appropriate control subjects. Approval for additional types of biospecimens may be obtained in the future.

Purpose

It is hoped that the stored biospecimens and associated clinical data will assist in the development of a much needed new taxonomy for TBI that will aid in improving research inclusion criteria, provide better prediction of clinical outcomes, and contribute to the development of relevant monitoring of outcomes following therapeutic interventions in TBI.