The UC Davis Mouse Biology Program (MBP) is happy to announce CRISPR-based genome editing (InDel, Exon Deletion [ExDel]) in murine embryonic stem (ES) cells and zygotes as a service for the academic scientific community. CRISPR technology can greatly reduce both the cost and time to generate mutant mouse models (e.g., knockouts) for scientific research. CRISPR can be used to create new mouse models, insert additional mutations, and modify pre-existing mutations in mouse models or ES cell lines. CRISPR allele modification including both conditional knock-out (cKO) genes and large Knock-in (KI) fragments up to 5kb are also available. We are happy to offer floxed cKO, KI (1bp to 5kbp), and inserting single nucleotide variants (SNVs) on an R&D basis.

As a leader in mutant mouse modeling and a participant in the NIH funded Knockout Mouse Project as well as the Mutant Mouse Resource & Research Center, the UC Davis MBP has invaluable experience in custom mouse model design and production. We pride ourselves in the services we provide to our fellow academic scientists. For more information, please click the “Contact Us” tab on the left-hand side of our website.