U-Pharm Laboratories, located in Parsippany, New Jersey, is aimed to help your drug discovery organizations meet these challenges. Whether your company is large or small, we are capable of supporting your firm with our dedicated pharmacology and discovery services.
Discovery biology services:
1. Pharmacology:
- Functional and binding assays and screening, e.g., Measurements: Ca2+, cAMP, PI, membrane potential, transport, phosphorylation, DMR, proliferation, ion-channel recordings
- Methods: fluorescence (FI, FP, FRET, TRF), Alphascreen, LANCE, luminescence, label-free, radioactivity, electrophysiology
- Drug targets: GPCRs, PDEs, transporters, ion channels, nuclear receptors, kinases and other enzymes.
- Compound screening (e.g., enzymes, GPCRs, transporters, cytotoxicity)
- SAR assay support
- Target selectivity profiling
2. Molecular Biology and Biochemical studies
- Gene cloning, expression and protein characterization
- Protein and antibody (Ab) purification, Ab screening
- Site-specific labeling
3. Cell Biology
- Stable cell line generation
- Cell culture service
4. Mechanistic studies
- Mechanism of action characterization