The genomics platform provides to basic, translational, and medical research teams with high throughput technological tools for analyzing gene structure and expression in various organisms, cellular models, and tumors.

Structural alterations in genomes, such as mutations, gains, amplifications, loss of genomic regions, polymorphisms, allelic imbalances, loss of heterozygosity are identified using SNP arrays, Nanostring analysis, Sanger sequencing, or qPCR.

Gene expression is complex and may be addressed at multiple levels. Coding and non-coding transcript for proteins can be quantified using Affymetrix chip for a pangenomic analysis, or using NanoString tools, or via qPCR depending on the number of samples and markers to quantify. The platform analyses the regulation of gene expression by quantifying microRNA, non-coding functional RNA, and other specific types of RNA, which modulate gene expression at various levels (transcription and translation). Such quantifications are performed by using Affymetrix chips or via NanoString multiplexing tools. Technics for quantifying certain epigenetic markers are currently being tested to meet internal demand (OxBS method developed by Cambridge Epigenetix).Other technics to analyse the chromatin conformation are being setup (in situ HiC, Uveal Melanoma project, with Pr. E. Heard) to enrich our portfolio of activities