The mission of TCMetrix is to provide researchers in clinical and basic sciences worldwide with innovative, state-of-the-art T cell monitoring reagents of high quality, to meet the increasing needs for conclusive and comprehensive MHC class I and class II T cell monitoring and analysis.

Because blood samples are precious and the value of T cell analysis critically depends on the quality of the reagents used, TCMetrix is committed to provide only highest quality reagents. Each reagent will be delivered with quality control data demonstrating the biochemical purity and integrity of the reagent and whenever possible with T cell staining data. In addition, each shipment will contain a product data sheet providing information on the stability of the reagent, the recommended storage and CD4+ and CD8+ T cell staining conditions.

While the primary focus is on the production of reagents for quantification and analysis of tumor antigen-specific T cell responses, TCMetrix endeavours to extend the scope of its services to other disorders, such as infectious diseases, autoimmunity and allergies. Because blood samples usually are small, T cell responses diverse and of low frequencies, especially tumor antigen specific ones, TCMetrix is developing parallel and sequential combinatorial staining strategies that use reversible and irreversible MHC-peptide multimers and antibodies and allow phenotypic and functional analysis on multiple CD8+ and/or CD4+ T cell specificities.

A major challenge for TCMetrix is to provide reagents and services that allow integral analysis of antigen-specific T cells for a better understanding of their diverse roles in adaptive immunity, in particular in cancer-specific immune reactions.

TCMetrix endorses the MIATA reporting framework and strongly encourages its adoption.