Synple Chem utilises a unique digital platform that consists of screenable, novel, diverse, and tractable chemical space, which is entirely accessible ‘on-demand’ using Synple’s automated cartridge-based synthesis technology. The combination of Synple-trained models and filters for creation of the chemical space, along with Synple’s pre-optimised automated reaction protocols ensures that molecules in the chemical space can be rapidly prepared in a highly predictable, automated manner. Machines and cartridges are available for in-house synthesis or molecules of interest can be ordered for synthesis by the Synple team, ensuring that all researcher have the opportunity to accelerate their discoveries.