Brief Description of Core: The Department of Biochemistry houses a state-of-the-art cryo transmission electron microscope (JEOL JEM-2100) equipped with cryo stage and digital imaging capabilities for observation of specimen at room and liquid nitrogen temperatures. The cryo TEM is suitable for observation of frozen hydrated specimen such as single protein molecules or two-dimensional crystals of membrane proteins. TVIPS EMMENU software allows automatic data collection for single molecule image analysis and cryo electron tomography.