Structure Based Design, Inc. is a leading Contract Research Organization (CRO) founded in 2007 in San Diego, California. We specialize in providing a ONE-STOP SERVICE that includes protein production, protein structure determination using X-ray crystallography and cryo-EM, assay development, compound library screening, and fragment-based drug design (FBDD) to support clients in lead discovery and early-stage drug development optimization.

Since our inception, we have worked on over 100 drug discovery projects and solved hundreds of co-crystal structures for our clients. Conveniently located in a biotech park in San Diego, we offer unparalleled scientific support through our in-house team of experienced scientists and state-of-the-art facilities.

Our clients include biotechnology companies, pharmaceutical firms, and academic laboratories. By employing structure-based design approaches, we accelerate first-in-class drug discovery efforts, saving years and millions of dollars in compound development. Drug discovery programs supported by our work have led to more than 30 clinical-stage compounds for our clients and more than 20 papers were published in top journals of drug discovery.