The Integrative Health Sciences Facility Core (IHSFC) plays a central role in achieving the research mission of the CEED. The IHSFC is the nexus for the Center’s interdisciplinary and translational research mission. Its goal is the integration of basic, translational, clinical, and epidemiological research. The IHSFC facilitates dialog among CEED members from different disciplines and provides guidance and training in design and implementation of studies in population (observational) epidemiology, clinical epidemiology, controlled exposure and clinical panel studies. This includes assistance with study design, subject recruitment, screening, management, and retention, questionnaire design, IRB issues, clinical procedures, clinical care, collection and processing of human samples for cellular, pathological and molecular analyses. The Core maintains the Center’s Laboratory Information Management System (LIMS), which integrates biological sample management and analysis by all Facility Cores. The IHSFC is also the portal for biostatistics, data management, archiving and security and facilitates bidirectional translation of clinical and animal studies.