The RPCI Data Bank and BioRepository Shared Resource (DBBR) prospectively collects and provides de-identified biospecimens and associated epidemiological and clinical data to investigators with IRB approved protocols. Newly diagnosed patients are consented for collection of blood tubes, completion of a risk factor questionnaire, and permission to link their samples to clinical data. DBBR samples and data can also be paired with tumor tissue from the Pathology Network Shared Resource and clinical data abstraction from the Clinical Data Network Shared Resource.