Skip to Main Content
OUTSOURCE EVERYTHING BUT THE GENIUS™

Go to Main Navigation

PharmOptima

Year Established:
2003
Website:
pharmoptima.com
Headquarters:
Portage, MI, US
Company Type:
Small Business (1-10M TTM Revenue)

PharmOptima provides lead selection and optimization services, in vivo efficacy studies, PK/PD analysis, drug metabolism profiling and PK ADME services.
Drug Development Services

• full range of pharmacokinetic and ADME services for IND/NDA
• vivarium with skilled technical staff
• LC-MS/MS method development and validation
• FDA Crystal City guidelines
• GLP compliant sample analysis

Biochemistry Services

• cell-based assays
• protein expression
o prokaryotic (E.coli)
o eukaryotic (mammalian, insect cell/baculovirus)
• protein purification
• ligand binding assays
• isothermal denaturation
• enzyme inhibitor characterization and mechanism
• fluorescence polarization and other fluorescence based assays
• biomarker assays
• ELISA
• MSD electrochemiluminescence

Bioanalytical Services

• rapid screening methods
• method development and validation
• FDA Crystal City
• OECD
• preclinical pharmacokinetics
• PK/PD assessment
• toxicokinetic investigations of absorption and clearance
• bioavailability/bioequivalence
• ocular PK
• cassette (n-in-1) dosing and analysis
• prodrug and metabolite PK

Assays and Assay Development

• immunosorbent assays
• traditional ELISA (HRP, AP)
• ECL (Meso Scale Discovery format) technologies
• development of multiplex immunoassays using MSD technology
• cell-based assays: signal transduction (eg cAMP)
• ligand binding assays
• radio-isotope
• isothermal denaturation
• fluorescence intensity and polarization
• enzyme assays and kinetics
• inhibitor mechanism and validation
• MSD Certification
• Human Aβ42
• Human Total Tau

Ophthalmic Research Services

• pharmacokinetics/ADME
• pharmacology and biochemistry
• specialized dosing
• specialized tissue and fluid collection
• precise sample processing and bioanalysis
• biomarker assays
• MSD electrochemiluminescence
• standard ELISA

Ocular Efficacy Models

• VEGF induced retinal vascular leakage (wet AMD)
• blue light damage (dry AMD)
• STZ induced diabetic retinopathy
• laser induced CNV
• LPS induced Uveitis
• allergic response

Site Badges
PharmOptima
6710 Quality Way Portage, MI, 49002 United States

Get started

To request access, simply fill out the form below and we will contact you.

Password must:

• Be at least 12 characters in length

• Contain a lowercase letter (a-z)

• Contain an uppercase letter (A-Z)

• Contain a numeral (0-9)

• Contain a special character (%, $, !, @)