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Year Established:
Portage, MI, US
Company Type:
Small Business (1-10M TTM Revenue)

PharmOptima provides lead selection and optimization services, in vivo efficacy studies, PK/PD analysis, drug metabolism profiling and PK ADME services.
Drug Development Services

• full range of pharmacokinetic and ADME services for IND/NDA
• vivarium with skilled technical staff
• LC-MS/MS method development and validation
• FDA Crystal City guidelines
• GLP compliant sample analysis

Biochemistry Services

• cell-based assays
• protein expression
o prokaryotic (E.coli)
o eukaryotic (mammalian, insect cell/baculovirus)
• protein purification
• ligand binding assays
• isothermal denaturation
• enzyme inhibitor characterization and mechanism
• fluorescence polarization and other fluorescence based assays
• biomarker assays
• MSD electrochemiluminescence

Bioanalytical Services

• rapid screening methods
• method development and validation
• FDA Crystal City
• preclinical pharmacokinetics
• PK/PD assessment
• toxicokinetic investigations of absorption and clearance
• bioavailability/bioequivalence
• ocular PK
• cassette (n-in-1) dosing and analysis
• prodrug and metabolite PK

Assays and Assay Development

• immunosorbent assays
• traditional ELISA (HRP, AP)
• ECL (Meso Scale Discovery format) technologies
• development of multiplex immunoassays using MSD technology
• cell-based assays: signal transduction (eg cAMP)
• ligand binding assays
• radio-isotope
• isothermal denaturation
• fluorescence intensity and polarization
• enzyme assays and kinetics
• inhibitor mechanism and validation
• MSD Certification
• Human Aβ42
• Human Total Tau

Ophthalmic Research Services

• pharmacokinetics/ADME
• pharmacology and biochemistry
• specialized dosing
• specialized tissue and fluid collection
• precise sample processing and bioanalysis
• biomarker assays
• MSD electrochemiluminescence
• standard ELISA

Ocular Efficacy Models

• VEGF induced retinal vascular leakage (wet AMD)
• blue light damage (dry AMD)
• STZ induced diabetic retinopathy
• laser induced CNV
• LPS induced Uveitis
• allergic response

Site Badges
6710 Quality Way Portage, MI, 49002 United States

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